New type of cancer treatment

[woo]

here is a basic diagram of a micelle. phospholipids have two opposing forces: hydrophobic and hydophillic which refer to what can not mix with water (like oil) and what can (Water solubles)
so these structures naturally form


the idea is the get the drug on the inside and find a way to make it break open and affect the cancer cells @ the location, instead of circulating and affecting healthy cells as much. high doses can be delivered to the site without raising the total blood concentration.

great awesome amazing idea and it is definitely feasible with a few approaches.

[MichelleT]

Because cancer is big business, and the FDA is in bed with the pharmacy companies so its in their best interest to put this guy in jail or make up some other lame legal excuse to prevent him from continuing his treatments.

i fucking hate people.

[fifi~dee]

yeah the nano-particle approach is gaining ground for more precise delivery. pple get sick bc of what radiation does to the entire body... but delivering the hot dose closer to the actual diseased site is being rigorously researched.

http://chemistrynewsarticles.blogspo...ws+Articles%29


MONDAY, JANUARY 30, 2012

Nanoparticles refined for more accurate delivery of cancer drugs
A new class of nanoparticles, synthesized by a UC Davis research team to prevent premature drug release, holds promise for greater accuracy and effectiveness in delivering cancer drugs to tumors. The work is published in the current issue of Angewandte Chemie, a leading international chemistry journal.

In their paper, featured on the inside back cover of the journal, Kit Lam, professor and chair of the Department of Biochemistry and Molecular Medicine, and his team report on the synthesis of a novel class of micelles called dual-responsive boronate cross-linked micelles (BCMs) , which produce physicochemical changes in response to specific triggers.


A micelle is an aggregate of surfactant molecules dispersed in water-based liquid such as saline. Micelles are nano-sized, measuring about 25-50 nanometers (one nanometer is one billionth of a meter), and can function as nanocarriers for drug delivery.


BCMs are a unique type of micelle, which releases the payload quickly when triggered by the acidic micro-environment of the tumor or when exposed to an intravenously administered chemical compound such as mannitol, an FDA-approved sugar compound often used as a diuretic agent, which interferes with the cross-linked micelles.


"This use of reversibly cross-linked targeting micellar nanocarriers to deliver anti-cancer drugs helps prevent premature drug release during circulation and ensures delivery of high concentrations of drugs to the tumor site," said first author Yuanpei Li, a postdoctoral fellow in Lam's laboratory who created the novel nanoparticle with Lam. "It holds great promise for a significant improvement in cancer therapy."


Stimuli-responsive nanoparticles are gaining considerable attention in the field of drug delivery due to their ability to transform in response to specific triggers. Among these nanoparticles, stimuli-responsive cross-linked micelles (SCMs) represent a versatile nanocarrier system for tumor-targeting drug delivery.


Too often, nanoparticles release drugs prematurely and miss their target. SCMs can better retain the encapsulated drug and minimize its premature release while circulating in the blood pool. The introduction of environmentally sensitive cross-linkers makes these micelles responsive to the local environment of the tumor. In these instances, the payload drug is released primarily in the cancerous tissue.


The dual-responsive boronate cross-linked micelles that Lam's team has developed represent an even smarter second generation of SCMs able to respond to multiple stimuli as tools for accomplishing the multi-stage delivery of drugs to the complex in vivo tumor micro-environment. These BCMs deliver drugs based on the self-assembly of boronic acid-containing polymers and catechol-containing polymers, both of which make these micelles unusually sensitive to changes in the pH of the environment. The team has optimized the stability of the resulting boronate cross-linked micelles as well as their stimuli-response to acidic pH and mannitol.


This novel nano-carrier platform shows great promise for drug delivery that minimizes premature drug release and can release the drug on demand within the acidic tumor micro-environment or in the acidic cellular compartments when taken in by the target tumor cells. It also can be induced to release the drug through the intravenous administration of mannitol.


The study was funded by grants from the National Institutes of Health and a Department of Defense Breast Cancer Research Program Postdoctoral Award. Other authors are Wenwu Xiao, Kai Xiao, Lorenzo Berti, Harry P. Tseng, and Gabriel Fung of UC Davis; and Juntao Luo of SUNY Upstate Medical University, Syracuse, New York.


Story Source:



The above story is reprinted from materials provided by University of California - Davis Health System.


Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

Yuanpei Li, Wenwu Xiao, Kai Xiao, Lorenzo Berti, Juntao Luo, Harry P. Tseng, Gabriel Fung, Kit S. Lam. Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis-Diols. Angewandte Chemie International Edition, 2012; DOI: 10.1002/anie.201107144

Truer words have never been spoken.
my father completed his 22nd of 30th radiation treatment (8 more to go) he has just been so ill from it. Not so much the chemo but the radiation has him drained, in pain, and sleeping nonstop

awesome article though

[DEEPER KEMICAL]

Because cancer is big business, and the FDA is in bed with the pharmacy companies so its in their best interest to put this guy in jail or make up some other lame legal excuse to prevent him from continuing his treatments.

Its a good documentary. This guy basically has the cure for cancer and he explains how he can cure brain tumors, which are the hardest to get rid of.

i can agree with this. my wife works in a cancer hospital and that place makes boat loads of money. its like a 5 star hotel. a transplant alone is a couple hundred thousand dollars

[woo]

Truer words have never been spoken.
my father completed his 22nd of 30th radiation treatment (8 more to go) he has just been so ill from it. Not so much the chemo but the radiation has him drained, in pain, and sleeping nonstop

awesome article though

wow im rooting for your dad! and anyone else in this fight. i love the creativity behind some research... $ can't buy that. passion for science is just priceless with some of the ideas they come up with.

i hope this one pans out. it seems promising.

[woo]

i can agree with this. my wife works in a cancer hospital and that place makes boat loads of money. its like a 5 star hotel. a transplant alone is a couple hundred thousand dollars

i think they try to make the long-term-stay hospitals more comfortable/homely and less "institutional" for the patients. many believe it helps with recovery.
transplants are so cumbersome. they just might always remain one of the priciest procedures bc of the pre-testing and post-op process is beyond most other procedures.

god bless your girl she can handle being around so many cancer patients. i heard a few times that dealing with cancer kids is the hardest of them all in medicine. THOSE hospitals are like high end artistic playgrounds.... rightfully so.

[DEEPER KEMICAL]

i think they try to make the long-term-stay hospitals more comfortable/homely and less "institutional" for the patients. many believe it helps with recovery.
transplants are so cumbersome. they just might always remain one of the priciest procedures bc of the pre-testing and post-op process is beyond most other procedures.

god bless your girl she can handle being around so many cancer patients. i heard a few times that dealing with cancer kids is the hardest of them all in medicine. THOSE hospitals are like high end artistic playgrounds.... rightfully so.

yea, the rooms are fully equipped with cable tv, wifi, xbox, computers etc. its like a mini apartment. it sounds amazing to us because we are healthy and dont have to go there, but the people there are really sick and these embellishments are there to make their 3,6,12 month stay more enjoyable.

she works mostly with adults, but time to time she has a child and its hard when she becomes close with them and they pass away.

flowers to the house and heart felt notes from the families are not uncommon. very very hard job.

[woo]

glad someone is willing to do it. i could never.

[TrippinFace101]

If they only catch it in time your days are numbered as soon your born.